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artR [2019-06-05 10:46:23]
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artR [2019-06-05 10:46:23]

high affinity arginine [SW|ABC transporter ](ATP-binding protein)
locus
BSU23960
pI
9.13
mw
26.80 kDa
protein length
240 aa Sequence Blast
gene length
723 bp Sequence Blast
function
arginine uptake
product
high affinity arginine [SW|ABC transporter ](ATP-binding protein)
essential
no
synonyms
artM,yqiZ
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.2|Uptake of amino acids]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.4|Biosynthesis/ acquisition of arginine]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    2,490,574 2,491,296

    The protein

    Protein family

  • [SW|ABC transporter superfamily] (according to UniProt)

    • Paralogous protein(s)

  • [protein|B24763A732111026D21C828FF9BE73FB22A123CF|TcyN], [protein|B453986691E1231A1C565D469A2A60EBFF2F6BD3|TcyC], [protein|F8C800CF71D21A1F3265977C4F0EE191D0FFE36A|YxeO], [protein|0D5BC94E21D51373A50D61CE3D0895B3DB28F6B3|PstBB], [protein|0F8048267EC038D8CF673317D969BA27735473A7|YvrO], [protein|468BEA9EAEA589D683DB79B2C689A5C6A22AB67F|GlnQ], [protein|434BCED6953BE07D592AC229264C5AD0D04CBAF6|PstBA]

    • Structure

  • [PDB|4YMS] (from Caldanaerobacter subterraneus, 44% identity) [pubmed|25848002]

    • [SW|Localization]

  • cell membrane (via [protein|62BD291B91DB0358754957D84A1F3636C247A697|ArtQ])

    • Expression and Regulation

    Operons

    genes
    [gene|8D9529D46E11D8B2826A98642706ADCBE1E3434A|artP]-[gene|62BD291B91DB0358754957D84A1F3636C247A697|artQ]-[gene|6882EF93EC82872B25C88104F62D6603D2514890|artR]
    description
    [Pubmed|12107147]

    regulatory mechanism

  • [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR]: regulation, [pubmed|30355672], in [regulon|F4097349A563503468A2A14F062AEAC532C7917A|YlxR regulon]

    • regulation

  • repressed by casamino acids [Pubmed|12107147]
  • induced in the absence of [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR] [pubmed|30355672]
    • view in new tab

    Biological materials

    Mutant

  • GP1689 Δ([gene|8D9529D46E11D8B2826A98642706ADCBE1E3434A|artP] - [gene|62BD291B91DB0358754957D84A1F3636C247A697|artQ] - [gene|6882EF93EC82872B25C88104F62D6603D2514890|artR])::''mls'', available in [SW|Jörg Stülke]'s lab
  • MGNA-C383 (yqiZ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2381 NBRP B. subtilis, Japan]
  • BKE23960 ([gene|6882EF93EC82872B25C88104F62D6603D2514890|artR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE23960 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AAATGATTTTGACAGCTTTT, downstream forward: _UP4_TAGAATATAAAAAAGAAGAA
  • BKK23960 ([gene|6882EF93EC82872B25C88104F62D6603D2514890|artR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK23960 BGSC], [Pubmed|28189581], upstream reverse: _UP1_AAATGATTTTGACAGCTTTT, downstream forward: _UP4_TAGAATATAAAAAAGAAGAA

    • References

  • 10092453,11423008,12107147,25848002